📋 Workflow
Full workflow, products add-to-cart directly1
Choose the solvent
15 minPick a single or mixed solvent where product dissolves hot/crystallizes cold and impurities stay soluble.
💡 Tip Use the minimum boiling solvent to reach saturation
⚠️ Caution Too-good solubility may give no crystals
🧪 Materials for this step (click to shop by spec/brand)
2
Dissolve by heating
20 minHeat the solvent under reflux, add solid in portions until just dissolved.
💡 Tip Add activated charcoal to adsorb colored impurities
⚠️ Caution Avoid excess solvent or yield drops
🧪 Materials for this step (click to shop by spec/brand)
3
Hot filtration
15 minFilter hot, hot-funnel/folded paper, to remove insoluble impurities.
💡 Tip Pre-warm the funnel to avoid crystallization on the filter
⚠️ Caution Cooling crystallizes and clogs the filter
🧪 Materials for this step (click to shop by spec/brand)
4
Cool and crystallize
1 hCool the filtrate slowly to room temperature, then ice; scratch the wall to seed if needed.
💡 Tip Slow cooling gives large, pure crystals
⚠️ Caution Rapid cooling traps mother-liquor impurities
🧪 Materials for this step (click to shop by spec/brand)
5
Filter, wash, and dry
30 minVacuum-filter on a Buchner funnel, wash with cold solvent, dry in oven or under vacuum.
💡 Tip Washing with cold mother liquor improves recovery/purity
⚠️ Caution Over-washing washes product away
🧪 Materials for this step (click to shop by spec/brand)
⚠️ 5 Common Beginner Mistakes
- ① Excess solvent, product never crystallizes
- ② Rapid cooling traps impurities
- ③ Heat loss precipitates product on the filter
- ④ Over-washing loses product
- ⑤ Wrong solvent fails to dissolve or crystallize
❓ FAQ
+No crystals form?
Seed or scratch; concentrate or swap solvent pair if needed.
+How to verify purity?
Melting point, single TLC spot, or HPLC purity.
+Which impurities are removable?
Insoluble, freely soluble, and crystallization-different impurities.