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🌡️ Separation & Purification · Method

Distillation / Fractionation

Separate liquids by boiling point
🎯 Difficulty ★★☆ Medium Duration About 2–5 h 🎯 Use Vaporize and condense a liquid to separate or purify by boiling point.
📖 Principle
Lowest-boiling component vaporizes and condenses first—distill fractions by temperature.
Below are 4 steps. Open each to see how to do it and add products to your shared list.

📋 Workflow

Full workflow, products add-to-cart directly
1

Assemble the still

20 min
Set up flask, still head, condenser, and receiver; check seals and airtightness.
💡 Tip Add boiling chips or a stir bar to prevent bumping
⚠️ Caution Poor sealing loses low-boiling components
🧪 Materials for this step (click to shop by spec/brand)
2

Atmospheric or vacuum distillation

1–3 h
Distill at controlled heating rate, record head temperature ranges, collect fractions.
💡 Tip Vacuum distillation prevents high-boilers from degrading
⚠️ Caution Use a buffer flask to prevent back-suction in vacuum
🧪 Materials for this step (click to shop by spec/brand)
3

Collect fractions

30 min
Collect each fraction over a distinct head-temperature range and label it.
💡 Tip Keep fractions separate for easier handling
⚠️ Caution Don't halt heating while switching receivers
🧪 Materials for this step (click to shop by spec/brand)
4

Identify the product

20 min
Confirm key fractions by refractive index, boiling point, or GC purity.
💡 Tip Refractive index vs literature is fast
⚠️ Caution High purity still needs GC quantitation
🧪 Materials for this step (click to shop by spec/brand)

⚠️ 5 Common Beginner Mistakes

  • No boiling chips causes bumping
  • Heating too fast drifts head temperature
  • Back-suction contaminates product under vacuum
  • Leaks lose low-boiling components
  • Atmospheric distillation degrades heat-sensitive product

❓ FAQ

+When to use vacuum distillation?
High boilers (>150℃) or thermally labile compounds.
+Similar boiling points?
Use a fractionating column or true rectification.
+How to avoid bumping?
Add boiling chips, magnetic stirring, or gas inlet.

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Data authenticity: Product categories from JW Supply Chain standard taxonomy; method→step→product connected. Last updated: 2026-08-23 · v3.0