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🔍 Virology · Method

Viral Detection

Detect and quantify viral nucleic acid/antigen
🎯 Difficulty ★★☆ Medium Duration About 3–6 h 🎯 Use Detect viral RNA/DNA or antigens in clinical or experimental samples for diagnosis and monitoring
📖 Principle
Extract viral nucleic acid then qRT-PCR amplifies/quantifies, or ELISA detects viral protein antigens
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📋 Workflow

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1

Sample collection and nucleic acid extraction

2 h
Collect samples (swab/blood/tissue) and extract viral nucleic acid
💡 Tip Add internal controls
⚠️ Caution Preserve sample integrity in transit
🧪 Materials for this step (click to shop by spec/brand)
2

qRT-PCR amplification

2 h
Run RT-qPCR with viral-specific primers/probes, quantify by Ct value
💡 Tip Include pos/neg controls and standard curve
⚠️ Caution Prevent aerosol contamination for false positives
🧪 Materials for this step (click to shop by spec/brand)
3

Antigen detection (optional)

2 h
Detect viral protein antigen by ELISA or rapid test strip
💡 Tip Antigen is fast but lower sensitivity
⚠️ Caution Watch detection window and false negatives
🧪 Materials for this step (click to shop by spec/brand)
4

Result interpretation

30 min
Call positive by Ct and/or antigen signal, verify validity with internal controls
💡 Tip Interpret with clinical/experimental context
⚠️ Caution Re-test when controls fail
🧪 Materials for this step (click to shop by spec/brand)

⚠️ 5 Common Beginner Mistakes

  • Aerosol contamination causes false positives
  • Nucleic acid degradation gives false negatives
  • Impure extraction inhibits amplification
  • Antigen window short leads to misses
  • Failed internal control invalidates results

❓ FAQ

+PCR vs antigen detection?
PCR sensitive, early, quantitative; antigen fast but less sensitive.
+How to prevent false positives?
Separate rooms, prevent aerosol, use dUTP/UNG and strict controls.
+What does higher Ct mean?
Higher Ct means lower viral load; above threshold is negative.

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Data authenticity: Product categories from JW Supply Chain standard taxonomy; method→step→product connected. Last updated: 2026-08-23 · v3.0