🏠 Home / By Experiment / Sample Prep / LLE 中文 EN
🧴 Sample Prep · Method

LLE

Partition extraction
🎯 Difficulty ★★☆ Medium Duration About 1–3 h 🎯 Use Transfer and concentrate analytes from aqueous into an organic phase
📖 Principle
Analytes distribute between immiscible phases by partition coefficient to separate and enrich
Below are 5 steps. Open each to see how to do it and add products to your shared list.

📋 Workflow

Full workflow, products add-to-cart directly
1

Solvent selection

15 min
Choose an organic solvent immiscible with water with good affinity for the target
💡 Tip Select solvent by analyte polarity
⚠️ Caution Mind solvent toxicity and volatility
🧪 Materials for this step (click to shop by spec/brand)
2

Add & shake

20 min
Add aqueous sample and extraction solvent to the funnel and shake thoroughly
💡 Tip Periodically vent to release pressure
⚠️ Caution Let it settle to separate layers
🧪 Materials for this step (click to shop by spec/brand)
3

Layer separation

20 min
After layering, carefully drain the lower or upper organic phase
💡 Tip Repeat extraction to raise recovery
⚠️ Caution Identify which layer is which
🧪 Materials for this step (click to shop by spec/brand)
4

Dry & concentrate

30 min
Dry the organic phase with anhydrous sodium sulfate and concentrate
💡 Tip Filter off the drying agent before concentration
⚠️ Caution Avoid high concentration temperature
🧪 Materials for this step (click to shop by spec/brand)
5

Reconstitute & inject

20 min
Reconstitute the concentrate in injection solvent for analysis
💡 Tip Mix well after making up to volume
⚠️ Caution Record volume and dilution factor
🧪 Materials for this step (click to shop by spec/brand)

⚠️ 5 Common Beginner Mistakes

  • Too few extractions lowering recovery
  • Insufficient settling causing cloudy layers
  • Improper venting spraying out liquid
  • Collecting wrong layer
  • Over-concentration losing sample

❓ FAQ

+How to judge clean layering?
Settle until the interface is clear and sharp.
+How many extractions?
Usually 2–3 times suffices for high recovery.
+Why dry?
Remove water that could interfere with analysis.

🧾 My Cart

Items selected on the product page are shared here
Nothing added yet
🛒 Go to Products
Data authenticity: Product categories from JW Supply Chain standard taxonomy; method→step→product connected. Last updated: 2026-08-23 · v3.0