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📏 Polymers & Macromolecules · Method

GPC

GPC for molecular weight distribution
🎯 Difficulty ★★☆ Medium Duration About 1–2 h 🎯 Use Use gel permeation chromatography to measure polymer molecular weight and distribution.
📖 Principle
Polymers of different sizes elute at different times, separating by dimension.
Below are 4 steps. Open each to see how to do it and add products to your shared list.

📋 Workflow

Full workflow, products add-to-cart directly
1

Prepare sample

30 min
Dissolve the polymer in the mobile phase (e.g., THF) and filter.
💡 Tip Full dissolution avoids artifacts
⚠️ Caution THF is flammable; ventilate
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2

Prepare standards

30 min
Prepare a series of known-molecular-weight polystyrene standards.
💡 Tip Standards should bracket the sample range
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3

Equilibrate & inject

30 min
Equilibrate at a set flow, then inject standards and samples in turn.
💡 Tip Constant flow keeps results comparable
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4

Data analysis

30 min
Build a calibration curve and compute Mw, Mn, and dispersity.
💡 Tip Note the standard system for relative MW
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⚠️ 5 Common Beginner Mistakes

  • Poor dissolution distorts peaks
  • Overload from too much sample
  • Temperature drift shifts retention
  • Contaminated mobile phase adds noise
  • Mismatched standards bias MW

❓ FAQ

+Is GPC absolute?
Usually relative; use light scattering for absolute.
+What if dispersity is large?
Broad distribution; check polymerization control.
+Switch mobile phase?
Use compatible columns and re-calibrate.

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Data authenticity: Product categories from JW Supply Chain standard taxonomy; method→step→product connected. Last updated: 2026-08-23 · v3.0