📋 Workflow
Full workflow, products add-to-cart directly1
Prepare the chiral catalyst
40 minMix metal salt and chiral ligand in anhydrous solvent to generate the active catalyst in situ.
💡 Tip Screen metal/ligand/additive ratios at small scale first
⚠️ Caution Ligand enantiopurity directly caps ee
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2
Substrate and conditions
20 minDissolve substrate, add precatalyst, set low temperature and stirring.
💡 Tip Low T and good dilution usually favor selectivity
⚠️ Caution Keep reaction anhydrous and O₂-free
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3
Run the asymmetric catalysis
4–10 hReact at set temperature/time; sample periodically for conversion and ee.
💡 Tip Measure ee by chiral HPLC or GC
⚠️ Caution Rapid warm-up erodes ee
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4
Workup and recycle
1 hQuench and extract; recover and recycle the chiral ligand/catalyst when possible.
💡 Tip Immobilized ligands simplify recycling
⚠️ Caution Monitor residual metal from catalyst
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5
Verify enantiopurity
40 minQuantify ee on a chiral column; confirm absolute configuration via rotation or derivatization.
💡 Tip Compare with chiral standard or literature
⚠️ Caution Don't assign configuration by rotation alone
🧪 Materials for this step (click to shop by spec/brand)
⚠️ 5 Common Beginner Mistakes
- ① Rac ligand caps ee
- ② Moisture destroys the active complex
- ③ Temperature drift drops selectivity
- ④ Wrong catalyst stoichiometry underperforms
- ⑤ Assigning configuration by rotation alone misleads
❓ FAQ
+Boost ee?
Lower T, use enantiopure ligand, tune stoichiometry, or swap ligand.
+Catalyst loading?
Typically 1–5 mol% when highly active.
+Confirm absolute configuration?
Single-crystal XRD or derivatize against known standard.