Immobilized enzyme for below hinge digestion of IgG in spin columns. FabRICATOR (IdeS) is an IgG-specific cysteine protease that digests antibodies at a single amino acid site below the hinge, generating homogenous F(ab’)2 and Fc fragments.

 The FabRICATOR Immobilized spin columns contain FabRICATOR enzyme covalently coupled to agarose beads, for digestion of IgG without contaminating the final preparation with enzyme.

 The spin columns are available for digestion of up to 0.5 mg (Microspin), 10 mg (Midispin) or 100 mg (Maxispin) IgG. The smallest columns are available in three different pack sizes, with 2, 5 or 10 columns per pack.
 

• Easy-to-use spin columns

• Increased enzyme-to-substrate ratio for improved digestion efficiency

• No enzyme in the final sample